pentobarbital will reduce the extent or effect of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.Keep an eye on Intently (one)mitotane decreases amounts of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. Mitotane is a solid inducer of cytochrome P-4503A4; keep tra